Allergic rhinitis: therapeutic strategies update Lactococcus lactis Plasma and tranilast–roxithromycin combination

• Yasuhiro Horiuchi ^[1]
  1. [1] Division of Dermatology, Tsuruse Orthopedic Clinic, Saitama, Japan.
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 52, Nº. 2, 2024, págs. 1-2
• Idioma: inglés
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• Resumen

  • * At present, there is no established definitive and reliable therapy for allergic rhinitis.

    * Combined effects of tranilast, which inhibits mast cell degranulation, and a specific macrolide antibiotic, roxithromycin, which has T helper 2 (Th2) cell inhibitory effects through ligands and receptors, may aid significantly in managing allergic rhinitis.

    * Lactococcus lactis strain Plasma (LC-Plasma) can induce plasmacytoid dendritic cells and consistent intake of LC-Plasma increases T helper 1 (Th1) responses, indicating a potential to suppress Th2 hypersensitivity conditions, such as allergic rhinitis.

    * A novel treatment approach for hay fever can now be chosen based on to the severity of the disease and amount of scattered pollen.