The role of sex and gender in the diagnosis and treatment of lung cancer: the 6th ICAPEM Annual Symposium

• Nuria Viñolas ^[1] ; Laura Mezquita ^[1] ; Jesús Corral ^[2] ; Manuel Cobo ^[3] ; Francisco Gil-Moncayo ^[4] ; Luis Paz-Ares ^[5] ; Jordi Remon ^[6] ; María Rodríguez ^[7] ; Alberto Ruano-Raviña ^[8] ; Esther Conde ^[9] ; Margarita Majem ^[10] ; Pilar Garrido ^[11] ; Enriqueta Felip ^[12] ; Dolores Isla ^[13] ; Javier de Castro ^[14]
  1. [1] Department of Medical Oncology, Barcelona Clinic Hospital, Translational Genomics and Targeted Therapies in Solid Tumours, IDIBAPS, Barcelona, Spain
  2. [2] Department of Medical Oncology, Jerez de la Frontera University Hospital, Cádiz, Spain
  3. [3] Department of Medical Oncology, Virgen de la Victoria University Hospital, Málaga, Spain
  4. [4] Department of Psycho-Oncology, Catalan Institute of Oncology-Hospitalet, Barcelona, Spain
  5. [5] Department of Medical Oncology, 12 de Octubre, University Hospital, Madrid, Spain
  6. [6] Department of Medical Oncology, HM Nou Delfos Hospital, Barcelona, Spain
  7. [7] Department of Thoracic Surgery, Clínica Universidad de Navarra, Madrid, Spain
  8. [8] Department of Medicine and Public Health, Santiago de Compostela University, Santiago de Compostela, Spain
  9. [9] Pathology Department, 12 de Octubre University Hospital, Universidad Complutense de Madrid, Research Institute 12 de Octubre University Hospital (Imas12), CIBERONC, Madrid, Spain
  10. [10] Department of Medical Oncology, Santa Creu y Sant Pau University Hospital, Barcelona, Spain
  11. [11] Department of Medical Oncology, Ramón y Cajal University Hospital, Madrid, Spain
  12. [12] Department of Medical Oncology, Vall d’Hebron University Hospital, Barcelona, Spain
  13. [13] Department of Medical Oncology, Lozano Blesa University Clinical Hospital, Saragossa, Spain
  14. [14] Department of Medical Oncology, La Paz University Hospital, Madrid, Spain

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 26, Nº. 2, 2024, págs. 352-362
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The incidence and mortality of lung cancer in women are rising, with both increasing by 124% between 2003 and 2019. The main risk factor for lung cancer is tobacco use, but indoor radon gas exposure is one of the leading causes in nonsmokers. The most recent evidence demonstrates that multiple factors can make women more susceptible to harm from these risk factors or carcinogens. For this consensus statement, the Association for Lung Cancer Research in Women (ICAPEM) invited a group of lung cancer experts to perform a detailed gender-based analysis of lung cancer. Clinically, female patients have different lung cancer profiles, and most actionable driver alterations are more prevalent in women, particularly in never-smokers. Additionally, the impact of certain therapies seems to be different. In the future, it will be necessary to carry out specific studies to improve the understanding of the role of certain biomarkers and gender in the prognosis and evolution of lung cancer.