Resumen de Zelula barneko zein jariatutako CEMIPek larruazaleko fibroblastoen mugikortasuna erregulatzen du

María Larrinaga Ruiz, Andrea Agüera Lorente, Ainhoa Alonso Pardavila, María Dolores Boyano López, Juan Manuel Falcón Pérez, Aintzane Asumendi Mallea, Aintzane Apraiz Garcia

• euskara

  CEMIP proteinaren adierazpena hantura kronikoari lotutako egoera patologikoetan deskribatu da, minbizia kasu. Egoera horietan, CEMIP matrize estrazelularraren berrantolaketarekin eta minbiziaren progresioarekin erlazionatu da. Lan honetan, CEMIPen eragina larruazaleko fibroblastoen mugikortasunean ikertu da, larruazaleko melanomaren mikroinguruneko oinarrizko zeluletan alegia. Bai melanoma zelulek zein fibroblastoek CEMIP jariatu dezaketela zehaztu ondoren, bi zelula horiek jariatutako CEMIPek larruazaleko fibroblastoen mugikortasuna erregulatzen duela frogatu da.

• English

  CEMIP is a protein with increased expression under chronic injlammation-involving conditions such as cancer, ofien linked to extracellular matrix remodeling and tumor progression. As shown in this work, motility of skin fibroblasts, key components of tumor microenvironment in cutaneous melanoma, was regulated by cellular CEMIP levels. Moreover, secreted CEMIP, both by fibroblasts and melanoma cells, was also able to modulate skinfibroblast migration