Thymus vulgaris ameliorates cough in children with asthma exacerbation: a randomized, triple-blind, placebo-controlled clinical trial

• Elnaz Eskandarpour ^[1] ; Adel Ahadi ^[2] ; Arezoo Moini Jazani ^[1] ; Ramin Nasimi Doost Azgomi ^[1] ; Rasol Molatefi ^[1]
  1. [1] Ardabil University of Medical Sciences

     Ardabil University of Medical Sciences

     Irán

     
  2. [2] Pediatric Department of BO-Ali Hospital, Ardabil University of medical sciences, Ardebil, Iran
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 52, Nº. 1, 2024, págs. 9-15
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Background: Asthma is one of the most common chronic respiratory diseases with inflammatory involvement and has a high burden worldwide. This study aimed to determine the effect of Thymus vulgaris (TV) on cough in children between 5 and 12 years old with mild to moderate asthma exacerbation.

    Methods: In this randomized, triple-blind clinical trial, 60 children between the ages of 5 and 12 with asthma exacerbations were randomly divided into two groups. The intervention group (n = 30) was given TV powder at a dose of 20 mg/kg every 8 hours, prepared as syrup, along with routine medical treatment for a week, and the control group (n = 30) received only routine medical treatment with placebo syrup. At the end of the week, clinical and laboratory symptoms, and spirometry data were re-recorded for both groups. Finally, the recorded factors were compared and statistically analyzed.

    Results: The results showed that after the intervention, activity-induced cough reduced, and difference was statistically significant between the two groups (p = 0.042), but the reduction in wheezing and breathlessness had no statistically significant difference. Spirometry data showed a significant difference in forced expiratory volume in 1 second (FEV1) between the two groups after intervention (p = 0.048), but this difference was not significant in FEV1/FVC (forced vital capacity), peak expiratory flow (PEF), and forced expiratory flow at 25–75% of the vital capacity (FEF25–75%).

    Conclusion: The results show that TV syrup may be useful as an adjuvant treatment in children with asthma exacerbations.