Lymphomas affecting the submandibular glands

• Gabriela Ribeiro de Araújo ^[1] ; Ana Luísa Morais-Perdigão ^[1] ; Cinthia Verónica Bardález Lopez-de-Cáceres ^[4] ; Oslei Paes de Almeida ^[4] ; Pablo Agustin Vargas ^[4] ; Elena María José Roman-Tager ^[4] ; Bruno Augusto Benevenuto de Andrade ^[2] ; Ciro Dantas Soares ^[5] ; Carlos Cesar de Oliveira Ramos ^[5] ; Maíra Medeiros Pacheco de Andrade ^[5] ; Alexandre de Oliveira Sales ^[5] ; Hélder Antônio Rebelo Pontes ^[3] ; Ricardo Alves Mesquita ^[1] ; Felipe Paiva Fonseca ^[1]
  1. [1] Universidade Federal de Minas Gerais

     Universidade Federal de Minas Gerais

     Brasil

     
  2. [2] Universidade Federal do Rio de Janeiro

     Universidade Federal do Rio de Janeiro

     Brasil

     
  3. [3] Universidad Federal de Pará

     Universidad Federal de Pará

     Brasil

     
  4. [4] Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil
  5. [5] Getúlio Sales Diagnósticos, Natal, Brazil

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 29, Nº. 1 (January), 2024
• Idioma: inglés
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• Resumen

  • Lymphomas affecting the submandibular glands are very uncommon and few reports are currently available in the literature. Therefore, the aim of the current study is to describe the clinical and microscopic features of an original series of lymphomas affecting the submandibular glands.

    The pathology files of two institutions were searched for lymphoma cases affecting the submandibular glands. The original hematoxylin and eosin, and immunohistochemical slides were revised by a pathologist for diagnosis confirmation following the revised 4th edition of the World Health Organization classification of tumours of haematopoietic and lymphoid tissues. Clinical data regarding age, sex, clinical manifestation, treatment, follow-up and status at last appointment were retrieved from the patients’ medical charts.

    During the period investigated, 16 cases were included in the study. Females predominated (10:6) with a mean age of 57.8 years-old. Tumors usually presented as asymptomatic swellings. MALT lymphoma represented the most common subtype, followed by diffuse large B cell lymphoma and follicular lymphoma. Three patients died, one of them affected by plasmablastic lymphoma, one by DLBCL and one by MALT lymphoma.

    Low-grade B cell lymphomas predominate in the submandibular glands, but DLBCL and other subtypes may also be rarely diagnosed in this salivary gland.