Resumen de Gut microbiota might mediate the benefits of high-fiber/acetate diet to cardiac hypertrophy mice

Meifang Chen, Liming Peng, Chenglong Zhang, Qiong Liu, Tianyi Long, Qiying Xie

• Continuously prolonged cardiac hypertrophy results in maladaptive myocardial remodeling, which afects cardiac function and can eventually lead to heart failure. Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, have been reported to be associated with cardiovascular diseases (CVD). Gut microbiota may mediate between dietary fber and SCFA efects on cardiac hypertrophy. The mice model of isoproterenol (ISO)-induced cardiac hypertrophy was constructed and verifed for physiological, functional, and fbrotic alterations in this study. Both high-fber and acetate diet improved physiological indexes, ameliorated cardiac functions, and relieved fbrotic alterations in model mice hearts; collectively, cardiac hypertrophy in mice receiving both high-fber and acetate diet improved. Following 16s rDNA sequencing and integrative bioinformatics, analyses indicated that both high-fber and acetate diet caused alterations in mice gut microbiota compared with the ISO group, including OTU composition and abundance. In conclusion, high-fber and acetate diet improve the physiological status, cardiac functions, and fbrotic alterations in ISO-induced hypertrophic mice. Besides, considering the alterations in mice gut microbiota in response to single ISO, both high-fber and acetate diet treatment, gut microbiota might mediate the favorable benefts of both high-fber and acetate diet on cardiac hypertrophy.