Twenty Years-Passed Case of Demineralized Dentin Matrix Autograft for Sinus Bone Augmentation - A First Case of Dentin Graft in Human -

Masaru Murata; Yukito Hirose; Morio Ochi; Junichi Tazaki; Naoto Okubo; Toshiyuki Akazawa

Ayuda

Twenty Years-Passed Case of Demineralized Dentin Matrix Autograft for Sinus Bone Augmentation - A First Case of Dentin Graft in Human -

Masaru Murata ^[3] ; Yukito Hirose ^[4] ; Morio Ochi ^[4] ; Junichi Tazaki ^[3] ; Naoto Okubo ^[1] ; Toshiyuki Akazawa ^[2]
1. [1] Hokkaido University
  
  Hokkaido University
  
  Chūō-ku, Japón
2. [2] Hokkaido Research Organization
  
  Hokkaido Research Organization
  
  Chūō-ku, Japón
3. [3] Division of Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido, Japan
4. [4] Division of Fixed Prosthodontics and Oral Implantology, School of Dentistry, Health Sciences University of Hokkaido, Japan
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Localización: Journal of Clinical and Experimental Dentistry, ISSN-e 1989-5488, Vol. 15, Nº. 10 (October), 2023, págs. 861-865
Idioma: inglés
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Resumen
- This report presents a 20-year follow-up of a unique case involving a 46-year-old man who underwent sinus augmentation using autogenous demineralized dentin matrix (DDM) derived from non-functional teeth. Two extracted molars were crashed into granules, and then demineralized, freeze-dried, and stored at -80° for approximately one year. The stocked DDM granules were grafted into the sinus along with platelet-rich plasma, without the use of any membrane. Radiographic evidence at 1 month after the graft demonstrated successful harmonization of the augmented tissues with the atrophic maxilla, as shown by the increase in radiopaque dots. Computed tomography scans taken 5 months post-procedure revealed clear sinuses devoid of inflammation, significant bone formation, and a smooth buccal side outline. Bone biopsies at 5 months were carried out from the implant sites, and three fixtures were placed into the augmented bone. The biopsy tissues confirmed the presence of continuous trabecular bone linked with DDM, with new bone formation observed on it. A comparison of the dental X-ray images taken in 2009 and those captured in 2021 indicated minimal change in the outline of the new bone formed near the fixture-necks through the DDM graft and successful placement of dental implants was achieved. Based on this long-term case study, it is suggested that autogenous DDM graft could serve as a minimally invasive alternative for sinus bone augmentation without invasive bone harvesting and the associated morbidities.