Effect of Different Exercise Training Modalities on Fasting Levels of Oxylipins and Endocannabinoids in Middle-Aged Sedentary Adults: A Randomized Controlled Trial

• Lucas Jurado Fasoli ^[1] ; Wei Yang ^[2] ; Isabelle Kohler ^[4] ; Manuel Dote Montero ^[1] ; Francisco J. Osuna Prieto ^[1] ; Xinyu Di ^[2] ; Thomas Hankemeier ^[2] ; Elke H.J. Krekels ^[2] ; Amy C. Harms ^[2] ; Manuel Joaquin Castillo Garzón ^[1] ; F. José Amaro ^[1] ; Borja Manuel Martínez Téllez ^[3]
  1. [1] Universidad de Granada

     Universidad de Granada

     Granada, España

     
  2. [2] Leiden University

     Leiden University

     Países Bajos

     
  3. [3] Universidad de Almería

     Universidad de Almería

     Almería, España

     
  4. [4] Division of BioAnalytical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, Noord-Holland, The Netherlands

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• Localización: International journal of sport nutrition and exercise metabolism, ISSN 1526-484X, ISSN-e 1543-2742, Vol. 32, Nº. 4, 2022, págs. 275-284
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • This study aimed to investigate the effects of different exercise training programs on fasting plasma levels of oxylipins, endocannabinoids (eCBs), and eCBs-like molecules in middle-aged sedentary adults. A 12-week randomized controlled trial was conducted using a parallel group design. Sixty-five middle-aged adults (40–65 years old) were randomly assigned to: (a) no exercise (control group), (b) concurrent training based on international physical activity recommendations (PAR group), (c) high-intensity interval training (HIIT group), and (d) HIIT together with whole-body electromyostimulation (HIIT + EMS group). Plasma levels of oxylipins, eCBs, and eCBs-like molecules were determined in plasma samples before and after the intervention using targeted lipidomics. Body composition was assessed through dual-energy X-ray absorptiometry, and dietary intake through a food frequency questionnaire and three nonconsecutive 24-hr recalls. The physical activity recommendations, HIIT, and HIIT-EMS groups showed decreased plasma levels of omega-6 and omega-3-derived oxylipins, and eCBs and eCBs-like molecules after 12 weeks (all Δ ≤ −0.12; all p < .05). Importantly, after Bonferroni post hoc corrections, the differences in plasma levels of omega-6 and omega-3 oxylipins were not statistically significant compared with the control group (all p > .05). However, after post hoc corrections, plasma levels of anandamide and oleoylethanolamide were increased in the physical activity recommendations group compared with the control group (anandamide: Δ = 0.05 vs. −0.09; oleoylethanolamide: Δ = −0.12 vs. 0.013, all p ≤ .049). In conclusion, this study reports that a 12-week exercise training intervention, independent of the modality applied, does not modify fasting plasma levels of omega-6 and omega-3 oxylipins, eCBs, and eCBs-like molecules in middle-aged sedentary adults.