Clinical Value of the Combination Detection of Captopril Renal Scintigraphy and Plasma Renin Activity in the Diagnosis of Renal Hypertension

• Qiannan Zhao ^[1] ; Jianfeng Shi ^[2] ; Yujuan Wu ^[3] ; Min Zhang ^[4] ; Shuyun Zheng ^[5] ; Xiaohua Wang ^[1]
  1. [1] Department of Clinical Laboratory, Yantaishan Hospital, 264003 Yantai, Shandong, China
  2. [2] Department of Clinical Laboratory, Yantai Qishan Hospital, 264001 Yantai, Shandong, China
  3. [3] Tumor Targeted Therapy Department, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital, 266000 Qingdao, Shandong, China
  4. [4] Department of Health Management, Jinan Zhangqiu District People’s Hospital, 250200 Jinan, Shandong, China
  5. [5] Department of Pediatrics, Jinan Zhangqiu District People’s Hospital, 250200 Jinan, Shandong, China

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• Localización: Archivos españoles de urología, ISSN 0004-0614, Tomo 76, Nº. 7 (September), 2023, págs. 532-537
• Idioma: inglés
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• Resumen

  • Objective: This study aimed to investigate the clinical value of the combination detection of captopril renal scintigraphy (CRS) and plasma renin activity (PRA) in the diagnosis of renal hypertension (RHR).

    Methods: Retrospective analysis was conducted on the clinical data of 163 patients with suspected RHR admitted to our hospital from March 2019 to March 2021, and all patients underwent blood pressure, CRS and digital subtraction angiography (DSA). The patients were divided into the positive group (n = 100) and the negative group (n = 63) in accordance with the results of DSA examination. PRA, angiotensin II and aldosterone levels of the two groups were detected and compared. The receiver operating characteristic curve was used to analyse the CRS, PRA and combined diagnostic performance.

    Results: The uptake ratio value after captopril intervention in the positive group was 36.71% ± 8.79%, which was significantly lower than that in the negative group (56.79% ± 10.09%, p < 0.05). The serum PRA level of the positive group was 4.70 ± 1.67 ng/mLꞏh, which was distinctly higher than that of the negative group (2.12 ± 1.03 ng/mLꞏh, p < 0.05). The sensitivity and Youden index under the combination detection (area under the curve (AUC) = 0.956, p < 0.001) were all higher than those under single detection.

    Conclusion: The combined detection of PRA and CRS can provide considerable evidence for the early diagnosis and treatment of RHR, which has a certain clinical value.