Therapeutic strategies and clinical evolution of patients with infantile fibrosarcoma: a unique paediatric case series
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María Dolores Corral Sánchez [1] ; Raquel Jiménez Carrascoso [2] ; Pedro Rubio Aparicio [1] ; Diego Plaza López de Sabando [1] ; Ana Sastre Urgelles [1] ; José Juan Pozo-Kreilinger [1] ; Juan Carlos López Gutiérrez [1] ; Manuel Gómez Cervantes [3] ; Eduardo José Ortiz Cruz [1] ; Antonio Pérez-Martínez [1]
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[1] Hospital Universitario La Paz
Hospital Universitario La Paz
Madrid, España
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[2] Universidad Autónoma de Madrid
Universidad Autónoma de Madrid
Madrid, España
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[3] Hospital Clínico San Carlos de Madrid
Hospital Clínico San Carlos de Madrid
Madrid, España
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 11 (November), 2023, págs. 3307-3311
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Background Infantile fibrosarcoma is the most frequent soft tissue sarcoma in newborns or children under one year of age. This tumour often implies high local aggressiveness and surgical morbidity. The large majority of these patients carry the ETV6–NTRK3 oncogenic fusion. Hence, the TRK inhibitor larotrectinib emerged as an efficacious and safe alternative to chemotherapy for NTRK fusion-positive and metastatic or unresectable tumours. However, real-world evidence is still required for updating soft-tissue sarcoma practice guidelines.
Objective To report our experience with the use of larotrectinib in pediatric patients.
Methods Our case series shows the clinical evolution of 8 patients with infantile fibrosarcoma under different treatments. All patients enrolled in this study received informed consent for any treatment.
Results Three patients received larotrectinib in first line. No surgery was needed with larotrectinib, which led to the rapid and safe remission of tumours, even in unusual anatomical locations. No significant adverse effects were observed with larotrectinib.
Conclusion Our case series supports that larotrectinib may be a therapeutic option for newborn and infant patients with infantile fibrosarcoma, especially in uncommon locations.
