Induction of perineural invasion in salivary adenoid cystic carcinoma by circular RNA RNF111

• RongBin Su ^[1] ; ShuSheng Zhong ^[1] ; PengHui Wang ^[1] ; ZhongWei Lin ^[2]
  1. [1] Department of Stomatology, Longyan People’s Hospital, Longyan, 364000, Fujian, China
  2. [2] Department of Radiology, Longyan People’s Hospital, No. 31, Denggao West Road, Xinluo District, Fujian Province, 364000, Longyan, China
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 11 (November), 2023, págs. 3152-3164
• Idioma: inglés
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• Resumen

  • Objective Local recurrence, distant metastasis, and perineural invasion (PNI) viciously occur in salivary adenoid cystic carcinoma (SACC), resulting in a poor prognosis. This study aimed to explore the mechanism by which circular RNA RNF111 (circ-RNF111) regulates PNI in SACC by targeting the miR-361-5p/high mobility group box 2 (HMGB2) axis.

    Method Circ-RNF111 and HMGB2 were highly expressed in SACC specimens, while miR-361-5p was underexpressed. Functional experiments showed that ablating circ-RNF111 or promoting miR-361-5p hindered the biological functions and PNI of SACC-LM cells.

    Results HMGB2 overexpression induced the reversal of SACC-LM cell biological functions and PNI caused by circ-RNF111 knockout. Furthermore, reduction of circ-RNF111 suppressed PNI in a SACC xenograft model. Circ-RNF111 regulated HMGB2 expression through targeted modulation of miR-361-5p.

    Conclusion Taken together, circ-RNF111 stimulates PNI in SACC by miR-361-5p/HMGB2 axis and may serve as a potential therapeutic target for SACC.