Emerging roles of long non-coding RNA FTX in human disorders

• Mohadeseh Sheykhi-Sabzehpoush ^[1] ; Majid Ghasemian ^[2] ; Fatemeh Khojasteh Pour ^[6] ; Mohammad Mighani ^[3] ; Mehdi Moghanibashi ^[4] ; Razieh Mohammad Jafari ^[7] ; Maciej Zabel ^[8] ; Piotr Dzięgiel ^[5] ; Maryam Farzaneh ^[7] ; Bartosz Kempisty ^[9]
  1. [1] Tehran University of Medical Sciences

     Tehran University of Medical Sciences

     Irán

     
  2. [2] Ahvaz Jundishapur University of Medical Sciences

     Ahvaz Jundishapur University of Medical Sciences

     Irán

     
  3. [3] Golestan University of Medical Sciences

     Golestan University of Medical Sciences

     Irán

     
  4. [4] Islamic Azad University

     Islamic Azad University

     Irán

     
  5. [5] Wrocław Medical University

     Wrocław Medical University

     Breslavia, Polonia

     
  6. [6] Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  7. [7] Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  8. [8] Division of Anatomy and Histology, University of Zielona Góra, 65-046, Zielona Góra, Poland
  9. [9] Department of Human Morphology and Embryology, Division of Anatomy, Wroclaw Medical, University, Wrocław, Poland

  Mostrar afiliaciones +
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 10 (October), 2023, págs. 2812-2831
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Long non-coding RNAs (lncRNAs) are involved the progression of cancerous and non-cancerous disorders via different mechanism. FTX (five prime to xist) is an evolutionarily conserved lncRNA that is located upstream of XIST and regulates its expression. FTX participates in progression of various malignancy including gastric cancer, glioma, ovarian cancer, pancreatic cancer, and retinoblastoma. Also, FTX can be involved in the pathogenesis of non-cancerous disorders such as endometriosis and stroke. FTX acts as competitive endogenous RNA (ceRNA) and via sponging various miRNAs, including miR-186, miR-200a-3p, miR-215-3p, and miR-153-3p to regulate the expression of their downstream target. FTX by targeting various signaling pathways including Wnt/β-catenin, PI3K/Akt, SOX4, PDK1/PKB/GSK-3β, TGF-β1, FOXA2, and PPARγ regulate molecular mechanism involved in various disorders. Dysregulation of FTX is associated with an increased risk of various disorders. Therefore, FTX and its downstream targets may be suitable biomarkers for the diagnosis and treatment of human malignancies. In this review, we summarized the emerging roles of FTX in human cancerous and non-cancerous cells.