Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer

• Shuai Li ^[1] ; Yulian Ma ^[2] ; Chen Wu ^[1] ; Xinfang Hou ^[1]
  1. [1] Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Henan Province, PR China
  2. [2] Henan Province Public Resources Trading Center, Henan Province, PR China
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 38, Nº. 8, 2023, págs. 907-916
• Idioma: inglés
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• Resumen

  • Kinesin family member 2C (KIF2C) was reported to act as a vital player in several human cancers. However, the exact function of KIF2C in gastric cancer (GC) is poorly understood. In the present study, the potential role of KIF2C was studied in gastric cancer by bioinformatics analysis and proliferation assay.

    KIF2C expression was detected using reverse transcription-quantitative polymerase chain reaction and western blot. Our data showed that the expression of KIF2C was increased in different tumor tissues, including GC. KIF2C was overexpressed in GC tissues and might be used as a diagnostic and prognostic biomarker for GC. KIF2C expression was correlated with immune infiltration and the levels of cell cyclerelated genes in GC. Moreover, silencing of KIF2C can cause cell cycle arrest, and inhibit the proliferative ability of GC cells. Thus, our studies revealed that KIF2C levels might serve as a promising biomarker for diagnosis and prediction of prognosis of GC, and targeting KIF2C might be an effective therapeutic strategy for GC.