Sex differences in vanadium inhalation effects in non-ciliated bronchiolar cells

• Nelly López-Valdez ^[1] ; Marcela Rojas-Lemus ^[1] ; Martha Patricia Bizarro-Nevares ^[1] ; Adriana Elizabeth GonzálezVillalva ^[1] ; Martha Luz Ustarroz-Cano ^[1] ; Brenda Casarrubias-Tabarez ^[1] ; Gabriela Guerrero-Palomo ^[1] ; María Eugenia Cervantes-Valencia ^[1] ; Norma Rivera-Fernández ^[1] ; Teresa Imelda Fortoul ^[1]
  1. [1] School of Medicine, National University of Mexico, Mexico
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 38, Nº. 7, 2023, págs. 765-777
• Idioma: inglés
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• Resumen

  • The non-ciliated bronchiolar cell (NCBC) is responsible for the defense of the lung and responds to negative stimuli such as exposure to toxic pro-oxidant substances, which triggers the hyperproduction and hypersecretion of mucins and CC16 protein. The literature demonstrates that physiological and pathological responses in the lung can be influenced by the organism’s sex. The objective of this report was to evaluate response differences to vanadium inhalation in male and female CD-1 mice. Mice were exposed to vanadium for four weeks. Hyperplasia of bronchiolar epithelium, small inflammatory foci and sloughing of the NCBC were observed, without changes between sexes and throughout the exposure time. Mucosecretory metaplasia was found in both males and females, however it was more drastic in males. The expression of CC16 increased in both sexes. This study demonstrated a different susceptibility between male and female mice exposed to vanadium inhalation regarding mucosecretory metaplasia.