Oral amyloidosis: an update

• Flávia Sirotheau Corrêa Pontes ^[1] ; Gabrielle Bastos Machado Ferreira ^[3] ; Felipe Paiva Fonseca ^[2] ; Tatiana Foscaldo Ribeiro Abreu Ribeiro ^[4] ; Patrícia Carlos Caldeira ^[2] ; Thalita Soares Tavares ^[2] ; Ana Paula Guerreiro Bentes ^[1] ; Márcio Ajudarte Lopes ^[5] ; Tarcília Aparecida da Silva ^[2] ; Jeanne Gisele Rodrigues de Lemos ^[3] ; Hélder Antônio Rebelo Pontes ^[1]
  1. [1] Universidad Federal de Pará

     Universidad Federal de Pará

     Brasil

     
  2. [2] Universidade Federal de Minas Gerais

     Universidade Federal de Minas Gerais

     Brasil

     
  3. [3] Graduate student, Oral Pathology Department, João de Barros Barreto University Hospital/Universidade Federal do Para, Belém, Pará, Brazil
  4. [4] Professor. Analytical Laboratory of Restorative Biomaterials (LABiom-R), School of Dentistry, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
  5. [5] PHD. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil

  Mostrar afiliaciones +
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 28, Nº. 4 (July), 2023
• Idioma: inglés
• Enlaces
  • Texto completo (pdf)
• Resumen

  • Amyloidosis is a disease characterized by the progressive deposition of abnormal proteins that can occur in any organ. In the oral cavity, the tongue is the most common affected site, usually causing macroglossia. Biopsy is essential for the diagnosis and the occurrence of its systemic form is mandatory to be investigated. This systematic review evaluated the existing information in the literature on Amyloidosis in the oral cavity to allow a more comprehensive and updated analysis of its clinicopathological characteristics, as well as to explore the main forms of treatment and prognostic factors.

    Electronic searches were undertaken in five databases supplemented by manual scrutiny.

    A total of 111 studies were included with 158 individuals.

    The disease had a higher prevalence in women, the tongue was the most affected site, as well as the systemic form of the disease. The worst prognosis was for cases of systemic amyloidosis associated with multiple myeloma.