Radiation therapy for vulvar cancer: consensus technical guidelines of the GINECOR working group of the Spanish Society of Radiation Oncology. Part 2: radiotherapy recommendations

• Sofia Cordoba Largo ^[1] ; Isabel Rodriguez Rodriguez ^[2] ; Silvia Rodriguez Villalba ^[9] ; Dina Najjari Jamal ^[3] ; Javier Anchuelo Latorre ^[4] ; Francisco Celada Álvarez ^[10] ; Sonia Garcia Cabezas ^[5] ; Cristina de la Fuente Alonso ^[1] ; Luz Couselo Paniagua ^[6] ; Irene Martínez Montesinos ^[11] ; Elena Villafranca Iturre ^[7] ; Belén Belinchón Olmeda ^[2] ; Dolores Farga Albiol ^[10] ; Paola Andrea Navarrete Solano ^[4] ; María Sánchez Belda ^[8] ; GINECOR Grupo Español de Tumores Ginecológicos de la SEOR
  1. [1] Hospital Universitario Puerta de Hierro

     Hospital Universitario Puerta de Hierro

     Madrid, España

     
  2. [2] Hospital Universitario La Paz

     Hospital Universitario La Paz

     Madrid, España

     
  3. [3] Universitat de Barcelona

     Universitat de Barcelona

     Barcelona, España

     
  4. [4] Hospital Universitario Marqués de Valdecilla

     Hospital Universitario Marqués de Valdecilla

     Santander, España

     
  5. [5] Hospital Universitario Reina Sofia

     Hospital Universitario Reina Sofia

     Cordoba, España

     
  6. [6] Complexo Hospitalario Universitario de Santiago

     Complexo Hospitalario Universitario de Santiago

     Santiago de Compostela, España

     
  7. [7] Hospital Universitario de Navarra

     Hospital Universitario de Navarra

     Pamplona, España

     
  8. [8] Hospital Universitario de Valladolid

     Hospital Universitario de Valladolid

     Valladolid, España

     
  9. [9] Departamento de Oncología Radioterápica, Hospital Clinica Benidorm, Benidorm, Alicante, España
  10. [10] Departamento de Oncología Radioterápica, Hospital Universitario y Politécnico La Fe, Valencia, España
  11. [11] Departamento de Oncología Radioterápica, Complejo Hospitalario de Navarra, Pamplona, España

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 7 (July), 2023, págs. 2169-2182
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Purpose The present consensus statement was developed by the GINECOR working group on behalf of the Spanish Society of Radiation Oncology (SEOR). This document provides an up-to-date review of the technical aspects in radiation treatment of vulvar cancer.

    Methods A two-round modified Delphi study was conducted to reach consensus on the appropriateness of technical aspects of external beam radiotherapy and brachytherapy. Three clinical scenarios were proposed: adjuvant treatment of vulvar cancer, radiation treatment of locally advanced vulvar carcinoma and locoregional recurrences. After the first round, an extensive analysis of current medical literature from peer-reviewed journal was performed to define evidence-based treatment options. In the second round, participants were asked to indicate their level of agreement with the preliminary recommendations according to the GRADE (Grade of Recommendation, Assessment, Development, and Evaluation) criteria, as follows: strongly agree; agree; neither agree nor disagree; disagree and strongly disagree.

    Results The main recommendations on external beam radiotherapy and brachytherapy, both in adjuvant setting and local advanced disease are summarized. Recommendations include treatment technique, treatment volume, and doses in target and organs at-risk. Taking into consideration the different clinical scenarios of recurrent disease, the radiation treatment should be individualized.

    Conclusions In the absence of robust clinical data, these recommendations may help to select the optimal radiotherapy approach for this relatively rare cancer.