Sex differences in the diagnosis, treatment and prognosis of cancer: the rationale for an individualised approach
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Ruth Vera [5] ; Oscar Juan-Vidal [1] ; María José Safont-Aguilera [2] ; Francisco Ayala de la Peña [3] ; Aránzazu González del Alba [4]
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[1] Hospital Universitario La Fe
Hospital Universitario La Fe
Valencia, España
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[2] Hospital General Universitario de Valencia
Hospital General Universitario de Valencia
Valencia, España
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[3] Hospital Morales Meseguer
Hospital Morales Meseguer
Murcia, España
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[4] Hospital Universitario Puerta de Hierro
Hospital Universitario Puerta de Hierro
Madrid, España
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[5] Servicio de Oncología Médica, Hospital Universitario de Navarra, Pamplona. IdiSNA, Instituto de Investigación Sanitaria de Navarra, Irunlarrea 3, 31190, Pamplona, España
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 7 (July), 2023, págs. 2069-2076
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Background Precision medicine in oncology aims to identify the most beneficial interventions based on a patient’s individual features and disease. However, disparities exist when providing cancer care to patients based on an individual’s sex.
Objective To discuss how sex differences impact the epidemiology, pathophysiology, clinical manifestations, disease progression, and response to treatment, with a focus on data from Spain.
Results Genetic and environmental factors (social or economic inequalities, power imbalances, and discrimination) that contribute to these differences adversely affect cancer patient health outcomes. Increased health professional awareness of sex differences is essential to the success of translational research and clinical oncological care.
Conclusions The Sociedad Española de Oncología Médica created a Task Force group to raise oncologists’ awareness and to implement measures to address sex differences in cancer patient management in Spain. This is a necessary and fundamental step towards optimizing precision medicine that will benefit all individuals equally and equitably.
