Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells

• Maryam Farzaneh ^[4] ; Ava Nasrolahi ^[5] ; Farhoodeh Ghaedrahmati ^[1] ; Tariq Masoodi ^[6] ; Sajad Najafi ^[2] ; Mohadeseh Sheykhi-Sabzehpoush ^[3] ; Mahrokh Abouali Gale Dari ^[7] ; Klaudia Radoszkiewicz ^[8] ; Shahab Uddin ^[9] ; Shirin Azizidoost ^[10] ; Seyed Esmaeil Khoshnam ^[11]
  1. [1] Isfahan University of Medical Sciences

     Isfahan University of Medical Sciences

     Irán

     
  2. [2] Shahid Beheshti University of Medical Sciences

     Shahid Beheshti University of Medical Sciences

     Irán

     
  3. [3] Tehran University of Medical Sciences

     Tehran University of Medical Sciences

     Irán

     
  4. [4] Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. [5] Infectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. [6] Laboratory of Molecular and Metabolic Imaging, Cancer Research Department, Sidra Medicine, 26999, Doha, Qatar
  7. [7] Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  8. [8] Translational Platform for Regenerative Medicine, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland
  9. [9] Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar
  10. [10] Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  11. [11] Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 7 (July), 2023, págs. 2015-2042
• Idioma: inglés
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• Resumen

  • Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.