The huge potential of targeting copper status in the treatment of colorectal cancer

• Zhengting Jiang ^[1] ; Gengyu Sha ^[1] ; Wenjie Zhang ^[1] ; Zhilin Zhang ^[1] ; Tian Liu ^[1] ; Daorong Wang ^[2] ; Dong Tang ^[2]
  1. [1] Yangzhou University

     Yangzhou University

     China

     
  2. [2] Department of General Surgery, Institute of General Surgery, Clinical Medical College, Northern Jiangsu People’s Hospital, Yangzhou University, Yangzhou, 225000, People’s Republic of China
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 7 (July), 2023, págs. 1977-1990
• Idioma: inglés
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• Resumen

  • Colorectal cancer (CRC) commonly leads to cancer deaths and is often diagnosed at advanced stages. It also faces difficulties due to the poor results of conventional treatments such as surgery, chemotherapy, and radiotherapy. Copper is a mineral nutrient whose intrinsic properties have a two-way effect on the production and treatment of cancer. Copper's redox properties allow it to be used in developing anti-cancer drugs, while its potential toxicity leads to oxidative stress and even cancer. Copper status is closely related to colorectal tumors’ proliferation and metastasis. The study of the mechanisms of copper homeostasis, cuproplasia, and cuproptosis due to altered copper status plays a crucial role in developing anticancer drugs. Therefore, targeting alteration of copper status becomes a potential option for treating colorectal cancer. This review summarizes the mechanisms by which altered copper status causes CRC progression and emphasizes the potential of regulating copper status in treating CRC.