Investigating the human rhinovirus co-infection in patients with asthma exacerbations and COVID-19

• Abdullah Al-Dulaimi ^[3] ; Ahmad R. Alsayed ^[4] ; Mohammed Al Maqbali ^[1] ; Malek Zihli ^[2]
  1. [1] Northumbria University

     Northumbria University

     Reino Unido

     
  2. [2] University of Jordan

     University of Jordan

     Jordania

     
  3. [3] MSc. Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman 11931-166, Jordan.
  4. [4] PhD, MSc, PharmD. Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman 11931-166, Jordan.

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• Localización: Pharmacy Practice (Granada), ISSN-e 1886-3655, Vol. 20, Nº. 2, 2022 (Ejemplar dedicado a: Apr-Jun)
• Idioma: inglés
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• Resumen

  • Objective: To investigate the co-infections with human rhinovirus (HRV) among patients with asthma exacerbation and COVID-19 in Jordan. Also, to determine the frequency of acute asthma exacerbation before and during the COVID-19 pandemic on a matched basis.

    Methods: The data of this prospective cohort research consisted of clinical variables. During the first visit, and after 14-days, nasopharyngeal swabs were taken and the quantitative polymerase chain reaction was performed for HRV and SARS-CoV-2 detection.

    Results: Forty-seven out of 175 (26.9%) COVID-19 adult cases have been diagnosed with asthma. The number of asthma exacerbations among the study participants was higher during 2021 than in 2020 (p=0.035). Most of the included asthmatic participants (61.7%) were only positive for SARS-CoV-2 and 38.3% were co-infected with HRV. The SARS-CoV-2 cycle threshold value was lower in samples infected with both viruses compared to samples infected with SARS-CoV-2 alone, p<0.005.

    Conclusion: Our findings indicate that HRV and SARS-CoV-2 were significantly more prevalent in asthma exacerbations than stable asthma. Thus, HRV and/or SARS-CoV-2 infections were potentially cofactors or contributors to the asthma exacerbation in this cohort. This is the first study, in Jordan, to investigate the HRV co-infection in COVID-19 asthmatic patients and HRV could be related with a higher severity of COVID-19.