Deposition and Clinical Impact of Inhaled Particles in the Lung

• Pere Casan Clarà ^[1] ; Francisco Rodríguez Jerez ^[2] ; José Belda Ramírez ^[3] ; Cristina Martínez González ^[1]
  1. [1] Universidad de Oviedo

     Universidad de Oviedo

     Oviedo, España

     
  2. [2] Hospital Universitario Clínico San Cecilio, Servicio de Neumología, Parque Tecnológico de la Salud, Granada, España
  3. [3] Fundación Fisabio, Hospital Arnau de Vilanova (Valencia), Facultad de Medicina de la Universidad Católica de Valencia, España

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• Localización: Archivos de bronconeumología: Organo oficial de la Sociedad Española de Neumología y Cirugía Torácica SEPAR y la Asociación Latinoamericana de Tórax ( ALAT ), ISSN 0300-2896, Vol. 59, Nº. 6 (June), 2023, págs. 377-382
• Idioma: inglés
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• Resumen

  • Particles suspended in the air we breathe are deposited in the airways as a function of the properties of the particle itself (shape, size and hydration), inspiratory air flow, airway anatomy, breathing environment, and mucociliary clearance. The scientific study of the deposition of inhaled particles in the airways has been conducted using traditional mathematical models and imaging techniques with particle markers. In recent years, the integration of statistical and computer methods, giving rise to a new discipline called digital microfluidics, has led to significant advances. In routine clinical practice, these studies are of great use for optimizing inhaler devices in line with particular characteristics of the drug to be inhaled and the pathology of the patient.