Food protein–induced enterocolitis syndrome due to buckwheat:: A case report

• Manabu Miyamoto ^[1] ; Masaya Kato ^[1] ; Shinya Yoshihara ^[1] ; Yoshihide Terashi ^[1] ; Koryo Nakayama ^[1] ; Fumitaka Takayanagi ^[1] ; Yusuke Ando ^[1] ; Yuji Fujita ^[1] ; Motoko Nakayama ^[1] ; Shigemi Yoshihara ^[1]
  1. [1] Dokkyo Medical University

     Dokkyo Medical University

     Mibu-machi, Japón

     
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 51, Nº. 3, 2023, págs. 25-27
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Buckwheat is a rare causative food for food protein–induced enterocolitis syndrome (FPIES). To date, it is unknown what laboratory data patients with FPIES caused by buckwheat show. We report a 4-year-old female with FPIES caused by buckwheat and the laboratory results. Skin prick, specific IgE antibody, and basophil activation tests were negative; however, the lymphocyte stimulation test (LST) revealed a 10.2-fold increase in activation compared with the negative control. In an open-label oral food challenge (OFC) of 80 g boiled buckwheat noodles, 3 hours after ingestion, vomiting occurred four times in a 2-hour duration. Therefore, we diagnosed the patient with FPIES caused by buckwheat. Her neutrophil count, C-reactive protein, and thymus and activation-regulated chemokine were elevated after the OFC. Moreover, the patient had a positive reaction to the LST, which may theoretically be useful in diagnosing non-immunoglobulin E-mediated gastrointestinal food allergies. FPIES caused by buckwheat is rare; however, we found that the same laboratory results were observed in a comparison of FPIES cases caused by other foods.