Islet Cell Therapy and Stem Cell Therapy for Type 1 Diabetes: There Will Always Be a Hope

• Betul A. Hatipoglu ^[1] ; Julia Blanchette ^[2]
  1. [1] Corresponding author. Department of Medicine, Adult Endocrinology, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106.
  2. [2] Division of Endocrinology, University Hospitals Cleveland Medical Center, Center for Diabetes and Obesity, 11100 Euclid Avenue, Cleveland, OH 44106, USA
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 52, Nº. 1, 2023, págs. 187-193
• Idioma: inglés
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• Resumen

  • To date, people living with type 1 diabetes depend on external subcutaneous insulin while waiting for a cure, or a feasible method to preserve, replace, and generate fully functioning β cells that secrete appropriate insulin in response to glucose. Current work includes evaluating renewable sources of β cells, transplantation methods without immunosuppressives, and methods to preserve β-cell function. Such methods include β-cell encapsulation, scaffolding, immune modulation, gene editing, and disease-modifying therapies. The purpose of this article is to review the progress and describe β-cell therapies over the past 5 years.