Tumor P70S6K hyperactivation is inversely associated with tumor-infiltrating lymphocytes in triple-negative breast cancer

Rebeca Gema Jimeno Lumeras; Silvana Mouron; Roberto Salgado; Sherene Loi; Belén Pérez Mies; Rodrigo Sánchez Bayona; Luis Manso Sánchez; Mario Martínez López; Ana Garrido García; Rosario Serrano; Ramón Colomer Bosch; Miguel Quintela-Fandino

Ayuda

Tumor P70S6K hyperactivation is inversely associated with tumor-infiltrating lymphocytes in triple-negative breast cancer

Rebeca Jimeno ^[3] ; Silvana Mouron ^[3] ; Roberto Salgado ^[4] ; Sherene Loi ^[4] ; Belén Pérez-Mies ^[1] ; Rodrigo Sánchez-Bayona ^[2] ; Luis Manso ^[2] ; Mario Martínez ^[2] ; Ana Garrido-García ^[5] ; Rosario Serrano-Pardo ^[6] ; Ramón Colomer ^[5] ; Miguel Quintela-Fandino ^[3]
1. [1] Hospital Ramón y Cajal
  
  Hospital Ramón y Cajal
  
  Madrid, España
2. [2] Hospital Universitario 12 de Octubre
  
  Hospital Universitario 12 de Octubre
  
  Madrid, España
3. [3] Unidad de Investigación Clínica en Cáncer de Mama, Programa de Investigación Clínica, CNIO, Madrid, España
4. [4] Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
5. [5] Departamento de Oncología Médica, Hospital Universitario La Princesa, Madrid, España
6. [6] Departamento de Patología, Hospital Universitario La Princesa, Madrid, España
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Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 4 (April), 2023, págs. 1124-1131
Idioma: inglés
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Resumen
- Purpose Triple-negative breast cancer (TNBC) is characterized by large heterogeneity and relative lack of available targeted therapies. To find therapeutic strategies for distinct patients with TNBC, several approaches have been used for TNBC clustering, including recently immune and phosphoproteomic patterns. Based on 70-kDa ribosomal protein S6 kinase (P70S6K)-TNBC clustering, the current study explores the immune profiling in TNBC tumors.
  
  Methods Stromal tumor-infiltrating lymphocytes (sTILs) were evaluated in human TNBC tumor samples. Furthermore, immunohistochemistry staining for CD8, CD4, Foxp3, and CD20 was performed in tissue microarrays (TMA) sections.
  
  Results Histological analysis showed decreased sTILs, CD20+ cells, and CD8+/CD4+ ratio in high phosphorylated P70S6K (p-P70S6K) tumors. Moreover, p-P70S6K score was directly correlated with CD4+ and Foxp3+ T cells, while it was inversely correlated with CD8+/CD4+ and CD8+/Foxp3+ ratios.
  
  Conclusion sTIL infiltration and lymphocyte profiling vary in the context of hyperactivation of P70S6K in TNBC tumors.