Mandibular Osteonecrosis Induced by Bisphosphonates in a Carrier of Chronicle Kidney Disease

• da Silva, Kaohana ^[2] ; de Oliveira, Greison ^[3] ; Garbin-Júnior, Eleonor ^[4] ; Magro-Érnica, Natasha ^[4] ; Griza, Geraldo ^[5] ; Conci, Ricardo ^[3] ; Seguin, Fabiana ^[1]
  1. [1] Universidade Estadual do Oeste do Paraná

     Universidade Estadual do Oeste do Paraná

     Brasil

     
  2. [2] Cirurgiã-Dentista, residente em Cirurgia e Traumatologia Bucomaxilofacial da Universidade Estadual do Oeste do Paraná – UNIOESTE / Hospital Universitário do Oeste do Paraná – HUOP.
  3. [3] Professor assistente do curso de Residência em Cirurgia e Traumatologia Bucomaxilofacial da Universidade Estadual do Oeste do Paraná – UNIOESTE / Hospital Universitário do Oeste do Paraná – HUOP.
  4. [4] Professor adjunto do curso de Residência em Cirurgia e Traumatologia Bucomaxilofacial da Universidade Estadual do Oeste do Paraná – UNIOESTE / Hospital Universitário do Oeste do Paraná – HUOP.
  5. [5] Professor assistente do curso de Residência em Cirurgia e Traumatologia Bucomaxilofacial da Universidade Estadual do Oeste do Paraná – UNIOESTE / Hospital Universitário do Oeste do Paraná – HUO.

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• Localización: International Journal of Medical and Surgical Sciences, (IJMSS), ISSN-e 0719-532X, ISSN 0719-3904, Vol. 4, Nº. 1, 2017 (Ejemplar dedicado a: March 2017), págs. 1119-1125
• Idioma: inglés
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• Resumen

  • The bisphosphonates are synthetic substances of inorganic pyrophosphate that have been the basis of treatment of patients with osteolytic diseases, such as multiple myeloma, malignant hypercalcemia, Paget's disease, or patients with bone metastases. Its main pharmacological effect is inhibition of bone resorption caused by osteoclasts, which have a reduced function. Their adverse effects are infrequent but include pyrexia, impaired renal function, hypocalcemia, and more recently, maxillo-mandibular ostenecrose induced bofosfonatos. In this report we describe a clinical case of jaw osteonecrosis induced by bisphosphonates in patient with chronic kidney disease and the treatment protocol performed.