Alterations in serum uric acid values in a sample of Nigerian pregnant women

• Wagbara, Chisom Clara ^[1] ; Alikor, Chizindu Akudubike ^[1]
  1. [1] University of Port Harcourt

     University of Port Harcourt

     Nigeria

     
• Localización: International Journal of Medical and Surgical Sciences, (IJMSS), ISSN-e 0719-532X, ISSN 0719-3904, Vol. 6, Nº. 4, 2019 (Ejemplar dedicado a: December 2019), págs. 111-114
• Idioma: inglés
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• Resumen

  •  Serum uric acid level is an important prognostic variable in pregnancy as subjects with preeclampsia have elevated serum uric acid levels. Methods: The concentrations of serum uric acid were investigated in 100 women of which 75 were pregnant women and categorized into 3 groups of 25 each, based on their trimesters of pregnancy and 25 non-pregnant women, which served as control.Results: In the first trimester, the mean values of uric acid were 122µmol/L with a decrease in the levels of uric acid when compared with the control levels of 308 µmol/L (p<0.05).In the second trimester, the values of uric acid were 199umol/l with a significant (p<0.05) decrease in the levels of uric acid when compared with the controls. In the third trimester of pregnancy, the values of uric acid were 360 µmol/L. There was a significant (p<0.05) increase in the level of uric acid when compared with the controls.Conclusion: The progressive increase in the levels of uric acid through the trimesters of pregnancy suggests an impairment in uric acid excretion, may be with concomitant increase in renal tubular re-absorption of uric acid, thereby leading to hyperuricaemia.