Acute high-intensity interval exercise is less pro-oxidative/thrombotic compared to isovolumic moderate-intensity steady-state exercise

• Fall, Lewis ^[2] ; Stacey, Benjamin S. ^[1] ; Calverley, Thomas ^[1] ; Owens, Thomas ^[1] ; Thyer, Kaitlin ^[1] ; Griffiths, Rhodri ^[1] ; Phillips, Rhodri ^[1] ; Bailey, Damian M. ^[1]
  1. [1] University of South Wales

     University of South Wales

     Pontypridd, Reino Unido

     
  2. [2] Neurovascular Research Laboratory, University of South Wales, Pontypridd, UK ; Faculty of Computing, Engineering and Science, University of South Wales, Pontypridd, UK
• Localización: Journal of physiology and biochemistry, ISSN-e 1877-8755, ISSN 1138-7548, Vol. 79, Nº. 1, 2023, págs. 35-46
• Idioma: inglés
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• Resumen

  • While high-intensity interval training (HIIT) has emerged as a more time-efficient alternative to moderate-intensity steady-state exercise (MISS), the impact on systemic free radical formation and link to activated coagulation remains unknown. We recruited sixteen healthy males aged 21 ± 3 y who performed incremental cycle ergometry to determine peak oxygen uptake (?˙O2 PEAK). Participants were randomly assigned single blind to two separate groups (MISS: n = 8; HIIT: n = 8) matched for ?˙O2 PEAK. HIIT participants completed five exercise cycles, each consisting of 3 min at 80%?˙O2 PEAK alternating with 3 min at 40% ?˙O2 PEAK, whereas MISS participants performed an isovolumic bout of 30 min at 60% ?˙O2 PEAK. Cephalic venous blood was assayed for ascorbate free radical (A•−, electron paramagnetic resonance spectroscopy) and clot fractal dimension (df, rheometry) at rest every hour over a 6-h period to determine critical difference (CD) and before/after submaximal/peak exercise. Submaximal MISS increased A• − and df to a greater extent compared to HIIT (P = 0.039 to 0.057) although elevations generally fell within CD boundaries (54.2% and 5.5% respectively). No further elevations were observed during peak exercise (P = 0.508 to 0.827) and no relationships were observed between A•− and df (r = 0.435 to − 0.121, P = 0.092 to 0.655). Collectively, these findings suggest that HIIT is less pro-oxidative/thrombotic compared to more traditional MISS, advocating its prescription in patients given the potential for superior vascular adaptive benefit.