What did we learn about coronavirus disease-19-associated acute kidney injury during the pandemic?
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Noemí del Toro-Cisneros [1] ; Adrián E. Caballero-islas [1] ; Juan C. Ramírez-Sandoval [1] ; Juan M. Mejía Vilet [1] ; Mauricio Arvizu Hernández [1] ; Gustavo Casas-aparicio [2] ; Jonathan Samuel Chávez Iñiguez [3] ; Lilia María Rizo Topete [4] ; Olynka Vega Vega [1]
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[1] Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
México
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[2] Instituto Nacional de Enfermedades Respiratorias
Instituto Nacional de Enfermedades Respiratorias
México
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[3] Hospital Civil de Guadalajara
Hospital Civil de Guadalajara
México
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[4] Universidad Autónoma de Nuevo León
Universidad Autónoma de Nuevo León
México
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- Localización: Revista de investigación clínica, ISSN 0034-8376, ISSN-e 2564-8896, Vol. 74, Nº. 6, 2022, págs. 287-301
- Idioma: inglés
- Enlaces
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Resumen
Initial reports suggested that kidney involvement after coronavirus disease 19 (COVID-19) infection was uncommon, but this premise appears to be incorrect. Acute kidney injury can occur through various mechanisms and complicate the course of up to 25% of patients with COVID-19 hospitalized in our Institution, and of over 50% of those on invasive mechanical ventilation. Mechanisms of injury include direct kidney injury and predominantly tubular, although glomerular injury has been reported, and resulting from severe hypoxic respiratory failure, secondary infection, and exposure to nephrotoxic drugs. The mainstay of treatment remains the prevention of progressive kidney damage and, in some cases, the use of renal replacement therapy. Although the use of blood purification techniques has been proposed as a potential treatment, results to date have not been conclusive. In this manuscript, the mechanisms of kidney injury by COVID-19, risk factors, and the mainstays of treatment are reviewed.
