A research review of experimental animal models with myelodysplastic syndrome

• Gen-Wang Chen ^[1] ; Mei-Na Chen ^[2] ; Lei Liu ^[1] ; Yu-Yu Zheng ^[1] ; Jin-Peng Wang ^[1] ; Si-Si Gong ^[1] ; Rong-Fu Huang ^[1] ; Chun-Mei Fan ^[1] ; Yue-Zu Chen ^[2]
  1. [1] Second Affiliated Hospital of Fujian Medical University

     Second Affiliated Hospital of Fujian Medical University

     China

     
  2. [2] Clinical Lab, Quanzhou Hospital of Traditional Chinese Medicine, Quanzhou, 362000, China
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 1 (January), 2023, págs. 105-113
• Idioma: inglés
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• Resumen

  • Myelodysplastic syndrome (MDS) consists of a group of hematologic tumors that are derived from the clonal proliferation of hematopoietic stem cells, featuring abnormal hematopoietic cell development and ineffective hematopoiesis. Animal models are an important scientific research platform that has been widely applied in the research of human diseases, especially tumors. Animal models with MDS can simulate characteristic human genetic variations and tumor phenotypes. They also provide a reliable platform for the exploration of the pathogenesis and diagnostic markers of MDS as well as for a drug efficacy evaluation. This paper reviews the research status of three animal models and a new spontaneous mouse model with MDS.