The pleiotropic mode and molecular mechanism of macrophages in promoting tumor progression and metastasis

• Xingxing Zhang ^[1] ; Wenxiu Bai ^[2] ; Lisha Hu ^[2] ; Hualan Ha ^[1] ; Yuelin Du ^[1] ; Wei Xiong ^[1] ; Hongbo Wang ^[1] ; Panfeng Shang ^[1]
  1. [1] Department of Urology, Institute of Urology, Gansu Nephro-Urological Clinical Center, Key Laboratory of Urological Diseases in Gansu Province, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China
  2. [2] Ultrasonic Special Examination Department, Tai An TSCM Hospital, Taian, 271000, Shandong, China
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 25, Nº. 1 (January), 2023, págs. 91-104
• Idioma: inglés
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• Resumen

  • Macrophages are the most abundant immune cells in primary and metastatic tumor tissues. Studies have shown that macrophages mainly exhibit a tumor-promoting phenotype and play a key role in tumor progression and metastasis. Therefore, many macrophage-targeted drugs have entered clinical trials. However, compared to preclinical studies, some clinical trial results showed that macrophage-targeted therapy did not achieve the desired effect. This may be because most of what we know about macrophages comes from in vitro experiments and animal models, while macrophages in the more complex human microenvironment are still poorly understood. With the development of technologies such as single-cell RNA sequencing, we have gained a new understanding of the origin, classification and functional mechanism of tumor-associated macrophages. Therefore, this study reviewed the recent progress of macrophages in promoting tumor progression and metastasis, aiming to provide some help for the formulation of optimal strategies for macrophage-targeted therapy.