Intraductal Carcinoma of the Prostate without High-Grade Invasive Adenocarcinoma: Report of Two Cases and Review of the Literature

• José Antonio Ortiz-Rey ^[1] ; Alejandro Bellas-Pereira ^[2] ; Pilar San Miguel-Fraile ^[1] ; Raquel Morellón-Baquera ^[2] ; Patricia Domínguez-Arístegui ^[3] ; Joaquín González-Carreró Fojón ^[1]
  1. [1] Instituto de Investigación Sanitaria Galicia Sur

     Instituto de Investigación Sanitaria Galicia Sur

     Vigo, España

     
  2. [2] Hospital Álvaro Cunqueiro

     Hospital Álvaro Cunqueiro

     Vigo, España

     
  3. [3] Servicio de Anatomía Patológica, Hospital Ribera Povisa, Vigo

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• Localización: Archivos españoles de urología, ISSN 0004-0614, Tomo 75, Nº. 9, 2022, págs. 738-745
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Objectives: Intraductal carcinoma of the prostate (IDC-P) is usually associated with high grade, aggresive acinar adenocarcinomas. IDC-P is supposed to result from the spread of the adenocarcinoma along the prostatic ducts. IDC-P rarely occurs without invasive carcinoma or with a coexistent low grade adenocarcinoma.

    Material and Methods: We report two patients, 66 and 75 year-old, who presented IDC-P and low-grade acinar adenocarcinoma foci in their radical prostatectomy surgical specimens.

    Results: Acinar adenocarcinomas were grade group 1, PTEN+, pT2. In the first case, the invasive adenocarcinoma was adjacent but nor intermingled with the IDC-P, and a discordance in the immunophenotype between them was outstanding (positivity for ERG in the acinar carcinoma being negative in the IDC-P). In the second case, the foci of adenocarcinoma were distant from the IDC-P. The first patient had not biochemical recurrence after a 34 month follow-up period.

    Conclusions: This kind of cases supports the existence of an infrequent subtype of IDC-P that could be considered as an in situ neoplasia.