Significant sise in SARS-CoV-2 reinfection rate in vaccinated hospital workers during the omicron wave: A prospective cohort study

• Eric Ochoa Hein ^[1] ; Patricia E. Leal Morán ^[1] ; Karen A. Nava-Guzmán ^[1] ; Abril T. Vargas Fernández ^[1] ; José F. Vargas Fernández ^[1] ; Fabricio Díaz-Rodríguez ^[1] ; Joel Armando Rayas-Bernal ^[1] ; Ricardo González González ^[1] ; Pavel Vázquez-González ^[1] ; Martha A. Huertas Jiménez ^[1] ; Sandra Rajme López ^[1] ; María del Pilar Ramos Cervantes ^[1] ; Violeta Ibarra González ^[1] ; Luis A. García-Andrade ^[1] ; Fernando Ledesma-Barrientos ^[1] ; Alfredo Ponce de León ^[1] ; José Sifuentes Osornio ^[1] ; Arturo Galindo Fraga ^[1]
  1. [1] Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

     Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

     México

     
• Localización: Revista de investigación clínica, ISSN 0034-8376, ISSN-e 2564-8896, Vol. 74, Nº. 4, 2022, págs. 175-180
• Idioma: inglés
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• Resumen

  • Background: Relatively low SARS-CoV-2 reinfection rates have been reported in vaccinated individuals, but updates considering the Omicron variant are lacking. Objective: The objective of the study was to provide a current estimate of the SARS-CoV-2 reinfection rate in a highly immunized population. Methods: A prospective cohort of Mexican hospital workers was followed (March 2020-February 2022). Reinfection was defined as the occurrence of two or more episodes of COVID-19 separated by a period of ≥ 90 days without symptoms. The reinfection rate was calculated as the number of reinfection episodes per 100,000 persons per day. Results: A total of 3732 medical consultations were provided to 2700 workers, of whom 1388 (51.4%) were confirmed COVID-19 cases. A total of 73 reinfection cases were identified, of whom 71 (97.3%) had completed their primary vaccination series and 22 (30.1%) had had a booster dose before the second episode. The overall reinfection rate was 23.1 per 100,000 persons per day (as compared to a rate of 1.9 per 100,000 persons per day before the Omicron wave). Conclusions: The SARS-CoV-2 reinfection rate rose significantly during the Omicron wave despite a high primary vaccination coverage rate. Almost one-third of reinfected workers had a vaccine booster ≥ 14 days before the last COVID-19 episode.