Gene expression profiling in breast cancer: from molecular portraits to personalized medicine

• Autores: Kornelia Polyak
• Localización: Revista de oncología: Publicación oficial de la Federación de Sociedades Españolas de Oncología y del Instituto Nacional de Cancerología de México, ISSN 1575-3018, Vol. 6, Nº. 4, 2004, págs. 192-202
• Idioma: español
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• Resumen

  • Technological advances made over the past decade and the completion of the human genome sequence have revolutionized molecular biology, and a similar revolution is expected in clinical medicine. Study of individual genes has turned into study of the "omes". In particular, the analysis of cancer transcriptomes has received wide spread attention and several important observations have been made. The molecular heterogeneity of breast carcinomas has been dissected leading to the recognition that breast cancer is not a single disease. The hope is that molecular classification of breast and other carcinomas will lead to a better understanding of the underlying tumorigenic processes and improved clinical management of patients. The speed at which data is collected has increased exponentially. However, the in depth analyses, comprehension, and translation into clinical practice are still lagging behind. Despite all these challenges, targeted drug design and individualized medical treatment are likely to become a reality in the near future in breast cancer as well as in other tumors and disease types