Preoperative sampling in endometrial cancer: evaluation of the histopathological agreement with definitive surgical specimen

• Raquel Quintana-Bertó ^[10] ; Pablo Padilla-Iserte ^[10] ; Antonio Gil-Moreno ^[1] ; Reyes Oliver-Pérez ^[2] ; Pluvio J. Coronado ^[3] ; María Belén Martín-Salamanca ^[4] ; Manuel Pantoja-Garrido ^[5] ; Cristina Lorenzo ^[11] ; Duska Beric ^[6] ; Juan Gilabert-Estellés ^[7] ; Lourdes Sánchez ^[8] ; Fernando Roldán-Rivas ^[12] ; Berta Díaz-Feijoo ^[13] ; José Ramón Rodríguez-Hernández ^[14] ; Josefina Marcos-Sanmartin ^[15] ; Juan Carlos Muruzábal ^[16] ; Antonio Cañada ^[9] ; Santiago Domingo ^[10] ; Sociedad Española de Ginecología y Obstetricia SEGO-GOG Group
  1. [1] Universitat Autònoma de Barcelona

     Universitat Autònoma de Barcelona

     Barcelona, España

     
  2. [2] Hospital Universitario 12 de Octubre

     Hospital Universitario 12 de Octubre

     Madrid, España

     
  3. [3] Hospital Clínico San Carlos de Madrid

     Hospital Clínico San Carlos de Madrid

     Madrid, España

     
  4. [4] Hospital Universitario de Getafe

     Hospital Universitario de Getafe

     Getafe, España

     
  5. [5] Hospital Universitario Virgen Macarena

     Hospital Universitario Virgen Macarena

     Sevilla, España

     
  6. [6] Hospital Universitario de Torrevieja

     Hospital Universitario de Torrevieja

     Torrevieja, España

     
  7. [7] Hospital General Universitario de Valencia

     Hospital General Universitario de Valencia

     Valencia, España

     
  8. [8] Hospital General de Ciudad Real

     Hospital General de Ciudad Real

     Ciudad Real, España

     
  9. [9] Instituto de Investigación Sanitaria La Fe

     Instituto de Investigación Sanitaria La Fe

     Valencia, España

     
  10. [10] Departamento de Ginecología Oncológica, Hospital Universitari y Politècnic La Fe, Av. Abril Martorell, 106, 46026, Valencia, España
  11. [11] Servicio de Ginecología y Obstetricia, Hospital Nuestra Señora de la Candelaria, Tenerife, España
  12. [12] Servicio de Ginecología y Obstetricia, Hospital Clínico Lozano Blesa, Zaragoza, España
  13. [13] Instituto Clínic de Ginecología, Obstetricia y Neonatología, Hospital Clinic de Barcelona, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, España
  14. [14] Servicio de Ginecología y Obstetricia, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, España
  15. [15] Servicio de Ginecología y Obstetricia, Hospital General Universitari D’Alacant, Alicante, España
  16. [16] Servicio de Ginecología y Obstetricia, Complejo Hospitalario de Navarra, Navarra, España

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 24, Nº. 12 (December), 2022, págs. 2388-2394
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Purpose The main goal of this study is to assess the diagnostic agreement between preoperative biopsy and definitive histology of the surgical specimen to determine which sampling method is most suitable for diagnosis of early-stage endometrial cancer.

    Methods We performed a retrospective multicentric study to assess the correlation between three endometrial sampling methods (hysteroscopy, pipelle and D&C) in patients who had undergone preoperative endometrial biopsy and received primary surgical treatment for endometrial cancer. The primary objective was the agreement rate between hysteroscopy (HSC), endometrial biopsy (pipelle) and dilatation and curettage (D&C).

    Results A total of 1833 women who underwent preoperative sampling at 15 centers were included: 1042 biopsies were performed by HSC, 703 by pipelle and 88 by D&C. All three methods presented a moderate diagnostic concordance (κ = 0.40–0.61) with the definitive specimen’s histology: HSC (κ = 0.47), pipelle sampling (κ = 0.48) and D&C (κ = 0.48). Likewise, a subgroup analysis was performed by histological subtype comparing HSC and endometrial biopsy, showing that neither is superior as a diagnostic method.

    Conclusions According to this study, the use of pipelle sampling could become an adequate diagnostic method in endometrial cancer due to its similar agreement to HSC, ease of use and affordability.