Resumen de Modelización de la variabilidad mutacional según la edad de los progenitores en ratones C57BL/6J
M. M. Castillo Roig, J.F. Medrano, Joaquim Casellas Vidal
New mutations are a very relevant component of polygenic variability. Nevertheless, the biological phenomena that originate new mutational variants are poorly understood, particularly in regard to the impacts that factors like a parent’s age may have. This research focuses on the analysis of weaning weight in 12,644 C57BL/6J mice from 46 non-overlapping generations. The analytical model used included systematic, permanent environmental and genetic sources of variation, and accounted for independent mutational contributions from each parent. This parameterization allowed us to clearly characterize different mutational patterns associated with the sex of the parent. Whereas the variability of the mutational load from male parents increased with age, mutational variance originating in female parents remained constant along the female’s reproductive lifespan.
