Resumen de Efectos aditivos, dominantes y epistáticos de los genes SCD y LEPR sobre el contenido y la composición de la grasa en cerdo
S. Gol, Roger Ros Freixedes, Marc Tor Naudi, Ramona Natacha Pena Subirá, N. Rothschild, J. Estany
A recent genome-wide association study in Duroc revealed two major loci affecting fat content in pig carcasses, which corresponded to the SCD and LEPR genes.While LEPR is associated with backfat thickness and intramuscular fat content, SCD affects their fatty acid composition. In this work, the additive, dominant and epistatic effects of one SNP at the promoter of the SCD gene and one SNP in exon 14 of the LEPR gene have been analyzed using data from 971 pigs of the same Duroc population. The SCD haplotype behaved additively, while the SNP in LEPR had complete dominance for some traits. Evidence of additive (SCD) per dominant (LEPR) epistatic effects were found on carcass weight and backfat thickness and on saturated and polyunsaturated fatty acids content. These two genes could be used as a model to better understand the epistatic effects of regulation of fat metabolism and deposition and to genetically improve meat and fat quality.
