Resumen de Identificación y validación de CNVs en porcino
M. Revilla, A. Puig Oliveras, D. Crespo Piazuelo, A.I. Fernández Cuesta, M. Ballester, J. M. Folch
The objective of this study was to identify copy number variants (CNVs) associated to growth traits and fatty acid composition in swine. Based on Control-FREEC software, we detected CNVs using the WGS of 7 individuals (2 Iberian boars and 5 Landrace sows). A total of 1,423 CNVs were identified with an average size of 198.64 kb in all individuals. Among them, 178 CNVRs were identified using a frequency of 1 for Iberian samples and 0-0.4 for Landrace. Using a frequency of 1-0.4 for Landrace and 0 for Iberian, 304 CNVRs were evidenced. 38 and 45 CNVRs respectively, overlapped with at least one of the selection criteria used. 59 genes located in these regions were identified after gene annotation. Interestingly, some of these genes (CLCA4, CYP4X1, KIT, MOGAT2 and PRKG1) have been previously associated with lipid metabolism. This study provided new insights into genomic structural variations that may be affecting economically relevant traits in pigs.
