The application value of CDFI and SMI combined with serological markers in distinguishing benign and malignant thyroid nodules

• Fang Li ^[1] ; Wei Sun ^[2] ; Lihua Liu ^[3] ; Zhen Meng ^[4] ; Jianli Su ^[5]
  1. [1] Department of Clinical Laboratory, Yantaishan Hospital, Yantai, 264000, Shandong, China
  2. [2] Outpatient Department, Qingdao Eighth People’s Hospital, Qingdao, 266100, Shandong, China
  3. [3] Department of ICU, The Affiliated Qingdao Central Hospital of Qingdao University, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, 266042, Shandong, China
  4. [4] Department of Ultrasound, Zhangqiu District People’s Hospital, Jinan, 250200, Shandong, China
  5. [5] Department of Clinical Laboratory, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266035, Shandong, China

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 24, Nº. 11 (November), 2022, págs. 2200-2209
• Idioma: inglés
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• Resumen

  • Purpose The purpose of this study is to explore the application value of CDFI and SMI combined with serological markers in distinguishing benign and malignant thyroid nodules.

    Method A total of 192 patients with thyroid nodules admitted to our hospital from July 2019 to December 2020 were selected as subjects. Color Doppler blood flow imaging (CDFI) and supermicro blood flow imaging (SMI) methods are used to detect the blood flow of patients and the levels of serum thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb), and thyroid stimulating hormone (TSH). The receiver operating characteristic curve (ROC curve) was used to observe the sensitivity and specificity of serological markers for distinguishing benign and malignant thyroid nodules, and combined with CDFI and SMI to observe the sensitivity and specificity for distinguishing benign and malignant thyroid nodules.

    Results The levels of TgAb, TPOAb and TSH in benign thyroid nodules were lower than those of the malignant group, and the difference was statistically significant (P < 0.01). There was no statistically significant difference between benign and malignant thyroid nodules in the presence or absence of the capsule and the presence or absence of vocal halo (P > 0.05), while the differences in the nodule morphology, boundary, internal echo and internal calcification were statistically significant (P < 0.01).

    Conclusion CDFI and SMI combined with serological index detection have higher value in the differential diagnosis of thyroid cancer, which can significantly improve the sensitivity and specificity of differential diagnosis.