Evidence for a new tumour suppresssor gene locus for y-radiation-induced thymic lymphoma located on the proximal part of mouse chromosome 18

• Autores: José Fernández Piqueras, María Matabuena Yzaguirre, Javier Santos Hernández
• Localización: Revista de oncología: Publicación oficial de la Federación de Sociedades Españolas de Oncología y del Instituto Nacional de Cancerología de México, ISSN 1575-3018, Vol. 6, Nº. 2, 2004, págs. 90-93
• Idioma: inglés
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• Resumen

  • Introduction. Five distinct thymic lymphoma suppressor regions have been identified on chromosome 4 (TLSR 1-5), and one on chromosome 19 (TLSR 8) through detection of loss of heterozygosity (LOH). Additionally, the involvement of p16/INK4a, p15/INK4b, p73, Pten and Fas had been reported in the most advanced stages of thymic lymphomagenesis.

    Material and methods. Advanced thymic lymphomas (n=110) induced by gamma-irradiation in F1 hybrids from a BALB/c and C57BL/6J cross were analysed using micro-satellite markers on chromosomes 13, 14 and 18.

    Results. Of the 110 tumours, 15 (14.5%) exhibited allelic losses on chromosome 18 at D18Mit21. Comparative analyses revealed significant differences (p<0.0001) for this marker and led us to define a new critical region of LOH on the proximal part of mouse chromosome 18, and named as TLSR9 according to the Mouse Nomenclature Committee.

    Conclusions. The proposed TLSR9 region is orthologous with 18q11 region, which is affected in various types of human cancers (Mitelman Database of Chromosome Aberrations in cancer (2002) Mitelman F, Johansson B and Mertens F (eds), http://cgap.nci.nih.gov/Chromosomes/Mitelman), and contains N-cadherin as a possible candidate gene.