Celiac Disease and Gastrointestnal Functonal Disorders
- Autores: Santos Santolaria Piedrafita
- Localización: Celiac Disease and Non-Celiac Gluten Sensitvity / coord. por Amado Salvador Peña; Luis Rodrigo (ed. lit.), 2014, ISBN 978-84-942118-2-9, págs. 347-362
- Idioma: inglés
- Enlaces
-
Resumen
Celiac disease (CD) is one of the most frequent genetc disorders diagnosed in the adultpopulaton and it may present a wide spectrum of gastrointestnal symptoms, which bear a largedegree of overlap with functonal dyspepsia, irritable bowel syndrome (IBS) or functonaldiarrhea. It has been demonstrated that CD, as diagnosed by positve serology and villousatrophy, is more frequent in patents with functonal dyspepsia (1.2-6.2%) and IBS (4.7-11.4%)than in the general populaton. This prevalence may be higher if we consider the whole spectrumof gluten-dependent mucosal histopathological lesions, including lymphocytc enteropathy.Consequently, patents with these gastrointestnal symptoms might be misdiagnosed with afunctonal bowel disorder if the diagnostc approach does not include CD-specifc antbody testsand duodenal biopsies. This fact might bring, as a result, a delay in CD diagnosis and treatment,with important consequences in terms of morbidity and quality of life. Non-celiac glutensensitvity is a clinical conditon characterized by symptoms that improve afer gluten withdrawal,negatve celiac serology and absence of enteropathy, which may be involved as a trigger in somefunctonal bowel disorders such as IBS.
