The development of MGE-derived cortical interneurons: An Lhx6 tale

• Autores: Ourania Christodoulou, Ioannis Maragkos, Vassiliki Antonakou, Myrto Denaxa
• Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 66, Nº. Extra 1-3, 2022 (Ejemplar dedicado a: Developmental Biology in Greece), págs. 43-49
• Idioma: inglés
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• Resumen

  • The cerebral cortex contains two main neuronal cell populations: the excitatory pyramidal neurons and the inhibitory interneurons, which constitute 20-30% of all cortical neurons. Cortical interneurons are characterized by a remarkable morphological, molecular and functional diversity. A swathe of research activity over the last 20 years has sought to determine how cortical interneurons acquire their mature cellular and functional features, and has identified a number of transcription factors that function at different stages of interneuron development. Here, we review all current knowledge concerning the multiple functions of the “master regulator” - LIM-Homeodomain transcription factor Lhx6 - a gene expressed in the medial ganglionic eminence of the basal telencephalon that controls the development of somatostatin and parvalbumin expressing interneurons.