The prognostic value of miR-487a in clear cell renal cell carcinoma and its influence on cell biological behavior

• Liu, Shuzhen ^[1] ; Zhao, Yuling ^[1] ; Zhao, Yubin ^[2] ; Tang, Xiaochun ^[1]
  1. [1] Traditional Chinese Medical Hospital of Huangdao District, China
  2. [2] Qingdao Central Hospital, China
• Localización: Archivos españoles de urología, ISSN 0004-0614, Tomo 75, Nº. 4 (Mayo), 2022, págs. 346-353
• Idioma: inglés
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• Resumen

  • Objectives: Clear cell renal cell carcinoma (ccRCC) is a type of kidney cancer that has a poor prognosis. microRNA-487a (miR-487a) plays a role in the prognosis of gastric cancer, liver cancer, and other cancers. The purpose of this study is to explore the role of miR-487a in the generation and progression of ccRCC.

    Materials and Methods: The RT-qPCR technology was used to detect the expression levels of miR-487a in ccRCC tissues and cell lines. The association between miR-487a and clinical-pathological characteristics of patients was analyzed using the chi-square test. Kaplan-Meier survival analysis and Cox regression analysis were used to analyze the prognostic significance of miR-487a in ccRCC. CCK-8 and Transwell assays were used to analyze the influences of miR-487a on cell proliferation, migration, and invasion.

    Results: miR-487a was significantly up-regulated in ccRCC tissues and cell lines. The high expression of miR-487a is related to lymph node metastasis and TNM staging and may be used as an independent prognostic factor related to lower overall survival and disease-free survival rate. Increased expression of miR-487a accelerated the proliferation, migration, and invasion of ccRCC cells.

    Conclusion: The enhanced expression of miR-487a was related to the prognosis of ccRCC, and it also facilitated cell proliferation, migration, and invasion.