Resumen de Stability omeprazole 2 mg/ml suspension for use in paediatrics in different acidic media

Khadija Rouaz, Blanca Chiclana Rodríguez, Anna Nardi Ricart, Marc Suñé Pou, Debora Mercadé Frutos, José María Suñé Negre, Pilar Pérez Lozano, Encarna García Montoya

• Compounding formulas are used in hospital settings to be able to cover the needs of special patients, such as paediatric, geriatric, or other patients with inability to swallow. According to data provided by the Vall d’Hebron Maternity and Children’s Hospital, omeprazole is one of the most active principles used in compounding formulas, for the treatment of gastrointestinal disorders in paediatric patients. The Omeprazole 2 mg/mL formulation in xanthan gum suspension is frequently used in hospital pharmacy services. Omeprazole is one of the Proton Pump Inhibitors (PPIs); the most widely used antisecretory drugs due to its efficacy and lack of significant adverse effects. Its stability depends on the pH: the degradation is fast in acidic medium but remains practically stable under alkaline conditions. For this reason, it is administered orally, in capsules containing enteric-coated granules, to prevent its ionization by the gastric acidic environment and promote its absorption in the duodenum