Formulation of a 3D printable hydrogel for the development of solid rectal drug delivery system
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Muñoz Perez E [1] ; Manuela Igartua Olaechea [1] [2] [3] ; Edorta Santos Vizcaíno [1] [2] [3] ; Rosa María Hernández Martín [1] [2] [3]
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[1] Universidad del País Vasco/Euskal Herriko Unibertsitatea
Universidad del País Vasco/Euskal Herriko Unibertsitatea
Leioa, España
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[2] Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, Spain
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[3] Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)
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- Localización: RESCIFAR Revista Española de Ciencias Farmacéuticas, ISSN-e 2660-6356, Vol. 2, Nº. 2, 2021 (Ejemplar dedicado a: XV CONGRESO DE LA SOCIEDAD ESPAÑOLA DE FARMACIA INDUSTRIA Y GALÉNICA), págs. 213-215
- Idioma: inglés
- Enlaces
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Resumen
Since the FDA approved the use of the first formulation manufactured by 3D printing in 2015, the application of this technology to obtain new and improved pharmaceutical formulations is on the rise. Nowadays, 3D printing is considered a reproducible, reliable, fast and easily manageable technique that allows a precise design of formulations. Thus, the high precision in manufacturing allows greater control over the characteristics and behaviour of each printed design. 3D printing of solid rectal formulations is particularly interesting as it offers an alternative for their production, obtaining results of greater morphological complexity and modified release profiles. Thus, the design of new printable materials suitable for their application in this field has become necessary. The aim of this project was to design and to evaluate a hydrogel composed by alginate and Laponite XLG as a bioink suitable for the obtainment of 3D-printed rectal formulations.
