Resumen de Caenorhabditis elegans as a model under hyperglicemic conditions to evaluate insulin-loaded nanoparticles
Ana L. Martínez López, Carlos J. González Navarro, José Luis Vizmanos Pérez, Juan Manuel Irache Garreta
The oral bioavailability of peptides therapeutics (e.g. insulin) is hampered by both the harsh gastrointestinal environment and poorly penetrating of biological barriers such as mucus layer. In order to solvent these issues and thus enhance the oral absorption of these macromolecules, one possible strategy may be their encapsulation into polymeric nanoparticles with mucus-penetrating properties. In this context, the aim of this work was to explore the potential of mucus-permeating nanoparticles based on the coating of zein nanoparticles (NP) with a polymer conjugate containing PEG (PPA), as carriers for the oral delivery of insulin. For this purpose, the resulting nanoparticles were characterized and their biodistribution and efficacy evaluated in rats and Caenorhabditis elegans (C. elegans), respectively.
