Hydroxyapatite and graphene oxide on nanocellulose-alginate ink for 3D bioprinting and bone regeneration

• Markel Lafuente Merchan ^{[1] [2] [3]} ; Sandra Ruiz Alonso ^{[1] [2] [3]} ; Laura Saenz del Burgo Martínez ^{[1] [2] [3]} ; José Luis Pedraz Muñoz ^{[1] [2] [3]}
  1. [1] Universidad del País Vasco/Euskal Herriko Unibertsitatea

     Universidad del País Vasco/Euskal Herriko Unibertsitatea

     Leioa, España

     
  2. [2] Centro de Investigación Biomédica en Red sobre Bioingeniería, Biomateriales y Nanomedicina

     Centro de Investigación Biomédica en Red sobre Bioingeniería, Biomateriales y Nanomedicina

     Madrid, España

     
  3. [3] Bioaraba, NanoBioCel Reseach Group, E-01009 Vitoria-Gasteiz, Spain

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• Localización: RESCIFAR Revista Española de Ciencias Farmacéuticas, ISSN-e 2660-6356, Vol. 2, Nº. 2, 2021 (Ejemplar dedicado a: XV CONGRESO DE LA SOCIEDAD ESPAÑOLA DE FARMACIA INDUSTRIA Y GALÉNICA), págs. 187-188
• Idioma: inglés
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• Resumen

  • The incidence of bone-related diseases has been increasing due to aging of the population. Up to now, therapeutic approaches have been focused on graft and titanium implants, which have been associated with infection, pain and implant rejection. Tissue engineering has become a promising treatment due to the use of scaffolds, which are designed to imitate as closely as possible the native tissue. In addition, three-dimensional (3D) bioprinting has become an emerging additive manufacturing technology in tissue engineering because of its rapid prototyping capacity and the possibility of creating complex structures. This study is focused on the development of nanocellulose-alginate (NC-Alg) based bioinks for 3D bioprinting for bone regeneration. Furthermore, hydroxyapatite (HAP) and graphene oxide (GO) were incorporate as they are biocompatible, bioactive and osteoconductive materials