Shear-collapsible microscale aggregates of PLGA nanoparticles with the ability to target obstructed blood vessels

• El-Hammadi, Mazen M ^[1] ; Otero Candelera, R ^{[2] [2] [3]} ; Martín Navarro, L ^[1] ; Álvarez Fuentes, J ^[1] ; Martin Banderas, L ^{[1] [2]}
  1. [1] Universidad de Sevilla

     Universidad de Sevilla

     Sevilla, España

     
  2. [2] Hospital Universitario Virgen del Rocío

     Hospital Universitario Virgen del Rocío

     Sevilla, España

     
  3. [3] CIBERES, Instituto de Salud Carlos III, Madrid, Spain.

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• Localización: RESCIFAR Revista Española de Ciencias Farmacéuticas, ISSN-e 2660-6356, Vol. 2, Nº. 2, 2021 (Ejemplar dedicado a: XV CONGRESO DE LA SOCIEDAD ESPAÑOLA DE FARMACIA INDUSTRIA Y GALÉNICA), págs. 52-53
• Idioma: inglés
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• Resumen

  • Obstruction of critical blood vessels as in thrombosis and aterosclerosis is a leading cause of death and long-term adult disability worldwide. Effective treatment requires quick and invasive interventions through the systematic infusion of thrombolytic agents or the placement of a catheter in the affected vessel. Moreover, non-selective distribution of the thrombolytic drug increases bleeding risk. Blood vessels with luminal stenosis (narrowing) show a significant increase in fluid shear stress (>1000 dyne/cm2) compared to normal vessels (~70 dyne/cm2), a fact that can be exploited for targeting delivery to obstructed vessels. The objective of present work is to prepare microscale aggregates of PLGA NPs with the ability to breakup under high shear stress into their forming NPs, which in turn adhere more effectively to the vessel surface compared with larger aggregates.