Polycaprolactone hybrid scaffolds combining 3D printing and electrospinning to guide the osteogenic differentiation of MC3T3 preosteoblasts for bone tissue regeneration

• Gonzalez Pujana, A ^{[2] [3] [4]} ; Hernando, S ^{[2] [3] [4]} ; Carranza,T ^[5] ; De La Caba, K ^{[1] [6]} ; Guerrero, P ^{[1] [6] [7]} ; Igartua, M ^{[2] [3] [4]} ; Santos Vizcaino, E ^{[2] [3] [4]} ; Hernandez, Rosa M ^{[2] [3] [4]}
  1. [1] Universidad del País Vasco/Euskal Herriko Unibertsitatea

     Universidad del País Vasco/Euskal Herriko Unibertsitatea

     Leioa, España

     
  2. [2] NanoBioCel Research Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the BasqueCountry (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria Gasteiz, Spain.
  3. [3] Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),Institute of Health Carlos III, Madrid, Spain
  4. [4] Bioaraba, NanoBioCel Research Group, Vitoria Gasteiz, Spain.
  5. [5] Domotek SL, Bº  Santa Luzi 17, 20400 Tolosa, Spain.
  6. [6] BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940,Leioa, Spain
  7. [7] Proteinmat materials SL, Avenida de Tolosa 72, 20018 Donostia-San Sebastián, Spain.

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• Localización: RESCIFAR Revista Española de Ciencias Farmacéuticas, ISSN-e 2660-6356, Vol. 2, Nº. 2, 2021 (Ejemplar dedicado a: XV CONGRESO DE LA SOCIEDAD ESPAÑOLA DE FARMACIA INDUSTRIA Y GALÉNICA), págs. 30-32
• Idioma: inglés
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  • Polycaprolactone (PCL), a synthetic linear hydrophobic polymer, has been widely used in tissue engineering over the last decade. This FDA approved polymer has been specially applied in the field of bone tissue engineering since it presents interesting features including a high biocompatibility, chemical stability and adequate mechanical properties. Different methods can be employed for the fabrication of PCL-based scaffolds for bone tissue regeneration. Among them, electrospinning is a versatile technique that generates a nanofibrous network that resembles the natural extracellular matrix (ECM), thus enhancing cell adhesion and promoting a correct cell function. On the other hand, 3D printed PCL scaffolds have demonstrated to enable cellular migration, vessel formation and in growth of tissue due to its architecture, which resembles the mechanical features of bone tissue. Taking advantage of the unique properties of PCL and the important advantages of both scaffold-fabrication techniques above mentioned, in the present work, we developed PCL hybrid scaffolds, comprised of a bioprinted PCL layer covered by electrospun nanofibers of such polymer. Obtained results showed the potential of this platform to drive the differentiation of MC3T3-E1 murine proteosteoblast towards bone tissue.