Resumen de SEOM—GECOD clinical guideline for unknown primary cancer (2021)

Ferran Losa, Isaura Fernández Pérez, Olatz Etxaniz Ulazia, Alejandra Giménez Ortiz, Paula Gomila, Lara Iglesias Docampo, Federico Longo Muñoz, Esteban Nogales, Antonio Sánchez, Gema Soler González

• Cancer of unknown primary site (CUP) is defined as a heterogeneous group of tumors that appear as metastases, and of which standard diagnostic work-up fails to identify the origin. It is considered a separate entity with a specific biology, and nowadays molecular characteristics and the determination of actionable mutations may be important in a significant group of patients. In this guide, we summarize the diagnostic, therapeutic, and possible new developments in molecular medicine that may help us in the management of this unique disease entity.