Pilar Barretina Ginesta, María Quindós Varela, Jesús Damián Alarcón, Carmen Esteban, Lydia Gaba, César Gómez Raposo, José Alejandro Pérez Fidalgo, Ignacio Romero Noguera, Ana Santaballa Bertrán, María Jesús Rubio Pérez
Endometrial cancer (EC) is the second most common gynecological malignancy worldwide, the first in developed countries [Sung et al. in CA Cancer J Clin 71:209–249, 2021]. Although a majority is diagnosed at an early stage with a low risk of relapse, an important proportion of patients will relapse. Better knowledge of molecular abnormalities is crucial to identify high-risk groups in early stages as well as for recurrent or metastatic disease for whom adjuvant treatment must be personalized. The objective of this guide is to summarize the current evidence for the diagnosis, treatment, and follow-up of EC, and to provide evidence-based recommendations for clinical practice.
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